Zycortal

What is Zycortal?

Zycortal is a veterinary medication used in endocrinology and hormone therapy for dogs. Its active ingredient is desoxycorticosterone pivalate (DOCP), a synthetic hormone belonging to the mineralocorticoid class. It is formulated as an injectable suspension specifically designed for canine use.
This medication replaces a hormone normally produced by the adrenal glands when they are no longer functioning properly. Zycortal has a long duration of action, allowing injections to be spaced out and helping maintain better hormonal stability in dogs affected by adrenal insufficiency.

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What is Zycortal used for?

Zycortal is indicated for the treatment of hypoadrenocorticism, more commonly known as Addison’s disease, in dogs. This condition occurs when the adrenal glands fail to produce sufficient amounts of essential hormones, particularly mineralocorticoids that regulate sodium and potassium balance in the body.
Electrolyte imbalances can lead to a variety of clinical signs, including:

• marked weakness or fatigue
• vomiting or diarrhea
• loss of appetite
• dehydration
• cardiac abnormalities in more advanced cases

By providing an external source of mineralocorticoids, Zycortal helps restore and maintain electrolyte balance, stabilizing the dog’s overall condition and reducing the risk of potentially life-threatening Addisonian crises.

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Dosage

Zycortal is available at a concentration of 25 mg/mL as an injectable suspension. The dosage is determined exclusively by the veterinarian, based on the dog’s weight, clinical condition, and blood test results.
Administration is typically performed every 3 to 4 weeks, although the exact interval may vary between dogs. Dose and frequency adjustments are primarily guided by monitoring blood sodium and potassium levels. Close veterinary supervision is essential to ensure optimal effectiveness while minimizing the risk of electrolyte imbalance.

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How and how often should I give Zycortal to my pet?

Zycortal is administered by injection, most often via the subcutaneous route, by a veterinarian or according to their specific instructions. It is not a medication intended for unsupervised home administration without proper training.
The usual schedule involves one injection approximately every 3 to 4 weeks, but this interval may be adjusted depending on the dog’s individual response. Regular blood testing is critical, especially at the start of treatment, to assess effectiveness and determine the appropriate timing of subsequent injections. In some cases, Zycortal is used in combination with a glucocorticoid, depending on the type and severity of hypoadrenocorticism.

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What are the side effects and precautions associated with Zycortal?

Zycortal is generally well tolerated by most dogs when administered under veterinary supervision. However, as with any hormonal therapy, mild and temporary side effects may occasionally occur.
Possible reactions include:

• pain, redness, or swelling at the injection site
• mildly increased thirst or urination
• temporary fluctuations in sodium and potassium levels

Close veterinary monitoring is essential, particularly during the initial treatment phase or when adjusting the dose. Regular electrolyte testing allows early detection of imbalances and timely intervention before complications develop.

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