Prednisone

What is Prednisone?

Prednisone is a corticosteroid used in veterinary medicine for its powerful anti-inflammatory and immunosuppressive properties. It is widely prescribed to treat various health conditions in dogs, including allergic reactions, acute inflammation, and certain autoimmune diseases.
Prednisone requires a veterinary prescription in Canada.

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What is Prednisone used for?

Prednisone is prescribed to:

• Reduce inflammation associated with skin, respiratory, joint, or gastrointestinal conditions.
• Control moderate to severe allergies in dogs.
• Suppress excessive immune responses, particularly in autoimmune diseases.
• Stabilize certain chronic conditions when first-line treatments are insufficient.

It acts quickly to relieve symptoms such as itching, swelling, pain, and tissue irritation.

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Dosage

Prednisone is available in tablet form in the following strengths:

• 1 mg (Windpred)
• 5 mg
• 50 mg

The exact dosage varies depending on the dog’s weight, the condition being treated, and the planned duration of therapy. Initial doses may be higher and are often gradually reduced based on clinical response. It is essential to follow your veterinarian’s instructions precisely.

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How and how often should I give Prednisone to my pet?

Prednisone is administered orally in tablet form. It may be given with or without food, although giving it with a small meal may help improve digestive tolerance.
Common dosing regimens include:

• Daily administration during the initial phase.
• Gradual tapering (every other day, then less frequently) as symptoms improve.

Abrupt discontinuation, especially after long-term treatment, can lead to serious complications related to adrenal insufficiency.

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What are the side effects and precautions associated with Prednisone?

Precautions

• Do not use in dogs with uncontrolled infections, gastrointestinal ulcers, or certain heart conditions.
• Inform your veterinarian of any other medications being given, as some anti-inflammatory drugs or antibiotics may interact with Prednisone.
• Ongoing monitoring is recommended for long-term treatment.

Possible side effects

• The most common effects include:
• Increased thirst and appetite
• Increased urination
• Weight gain
• Restlessness or lethargy, depending on the dog
• With long-term use: risk of immunosuppression, thinning of the skin, muscle weakness, or secondary infections

Side effects are dose-dependent and tend to decrease as the dosage is reduced. If you notice unusual reactions, contact your veterinarian.

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