What is NexGard COMBO?
NexGard COMBO is a veterinary antiparasitic medication intended exclusively for cats. It is a topical solution (pipette) applied directly to the skin, usually at the base of the neck where the cat cannot lick. Its innovative formula combines three well-recognized active ingredients: esafoxolaner, eprinomectin, and praziquantel.
This combination provides broad-spectrum action, targeting both external and internal parasites. NexGard COMBO stands out for its ease of use and the fact that a single product covers multiple antiparasitic needs, reducing the number of treatments required for your cat.
Specifically developed for the feline species, NexGard COMBO is widely used in Canada as part of veterinarian-recommended prevention programs.
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What is NexGard COMBO used for?
NexGard COMBO is used to protect cats against a wide range of parasites. It acts against external parasites such as fleas, while also treating and preventing several internal parasites, including certain intestinal worms.
Thanks to its combined action, NexGard COMBO helps preserve your cat’s overall health by reducing the risk of multiple infestations, which can cause discomfort, digestive issues, or other complications if left untreated.
When administered regularly, NexGard COMBO fits perfectly into a monthly prevention strategy and is especially useful for indoor and outdoor cats, or those in contact with other animals.
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Dosage
NexGard COMBO dosage is determined based on the cat’s weight. It is essential to use the pipette corresponding to the correct weight range to ensure optimal effectiveness and safe use.
Available presentations include:
- Cats under 2.5 kg: box of six 0.3 mL pipettes
- Cats weighing 2.5 to 7.4 kg: box of six 0.9 mL pipettes
Each pipette contains a precise concentration of active ingredients (esafoxolaner, eprinomectin, and praziquantel) adapted to the animal’s weight. NexGard COMBO must not be used in cats weighing less than the recommended range for the selected presentation. Your veterinarian will determine the appropriate format at the time of prescription.
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How and how often should I give NexGard COMBO to my pet?
NexGard COMBO is administered topically using a ready-to-use pipette. The contents of the pipette should be applied directly onto the skin, usually between the shoulder blades or at the base of the neck, after parting the fur.
The dosing frequency is monthly. One application per month helps maintain continuous protection against the targeted parasites. It is recommended to apply the product on the same date each month to ensure consistent prevention and avoid missed doses.
After application, prevent the cat from licking the treated area or having close contact with other animals until the solution has dried. Always follow your veterinarian’s instructions and those provided on the product packaging.
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What are the side effects and precautions associated with NexGard COMBO?
NexGard COMBO is generally well tolerated by cats when used according to veterinary recommendations, but like any medication, mild and transient side effects may occasionally occur.
Possible effects may include:
- Temporary skin reactions at the application site, such as redness, mild itching, or localized hair loss
- Temporary excessive salivation if the product is accidentally licked
- Mild decrease in appetite or short-term behavioural changes
NexGard COMBO is intended for feline use only and must never be administered to other species. Avoid ingestion of the product and strictly follow application instructions. Always inform your veterinarian if your cat has specific health conditions or is receiving other treatments.
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Frequently asked questions aboutNexGard COMBO
Can I buy NexGard COMBOwithout a prescription?
How long does it take forNexGard COMBOto work
What should I do if I miss a dose ofNexGard COMBO?
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Warning

Any medication or natural health product may cause serious side effects or interact with other medications. It is essential to carefully reads the labels, warnings, and brochures provided by the manufacturer, and consult your pharmacist or veterinarian when purchasing products. Always keep medications and natural health products out of reach of children.
The medications and pharmaceutical services presented on anipharm.ca are exclusively provided by the pharmacists of Maël Robert-Lamarre pharmacien Inc., affiliated with AniPharm.
These services are offered solely under the responsibility of Maël Robert-Lamarre Pharmacist Inc. Specific conditions may apply – please consult your pharmacist.
The pharmacy owner, Maël Robert-Lamarre, is solely responsible for the operation of the pharmacy.
In case of emergency or for any questions regarding your pet’s health, please consult your veterinarian.

